The Killarney Guest House is located across the road from the University College of Cork. Guests will find many attractions in the surrounding area, including Blackrock Castle, Blarney Castle, and Grand Parade. Father Matthew Memorial Church and Red Abbey Tower are also located quite nearby. The Killarney Guest House is located within easy reach of Cork International Airport. The airport and other attractions can be easily reached via rental car service or taxi cab, and the hotel offers a complimentary onsite car park.

All of the guestrooms at the Killarney Guest House are well decorated. Each room offers a television as well as climate controls and a phone. All rooms include private bathrooms with hair dryers and ironing boards, and many also offer whirlpool tubs.

Guests will find many shops and restaurants near the Killarney Guest House. There is a restaurant located right onsite as well as a lovely breakfast. The hotel also offers off street parking and an array of other amenities.